表皮生长因子受体

来自医学百科

模板:PBB/1956 表皮生长因子受体英文名:epidermal growth factor receptor,简称为EGFRErbB-1HER1)是一类名为表皮生长因子家族(EGF-家族)的细胞蛋白配体细胞表面受体[1]

表皮生长因子受体是ErbB受体家族家族的成员之一,ErbB家族是包含四种紧密联系蛋白的亚家族,这四种蛋白分别是受体酪氨酸激酶类:EGFR(ErbB-1)HER2/c-neu(ErbB-2)、Her 3(ErbB-3)以及Her 4(ErbB-4)。影响EGFR表达或活性的突变可能导致癌症[2]

表皮生长因子及其受体是由范德堡大学的斯坦利·科恩发现的,科恩与丽塔·列维-蒙塔尔奇尼因发现生长因子类而共同获得了1986年诺贝尔生理学或医学奖

功能

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EGFR信号传导级联

表皮生长因子受体(EGFR)存在于细胞表面且因结合特异性受体而被激活,这些受体包括表皮生长因子和TGFα。ErbB2并无已知的直接激活配体,可能结构性地处于激活状态,或在与如EGFR等其他家族成员形成异源二聚体时被激活。

参考文献

  1. Herbst RS. Review of epidermal growth factor receptor biology. Int. J. Radiat. Oncol. Biol. Phys.. 2004, 59 (2 Suppl): 21–6. Error: Bad DOI specified模板:Namespace detect showall. PMID 15142631. 
  2. Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1934579/ ErbB receptors: from oncogenes to targeted cancer therapies]. J. Clin. Invest.. August 2007, 117 (8): 2051–8. Error: Bad DOI specified模板:Namespace detect showall. PMID 17671639. PMC 1934579. 

深入阅读

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  • Filardo EJ. Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. J. Steroid Biochem. Mol. Biol.. 2002, 80 (2): 231–8. Error: Bad DOI specified模板:Namespace detect showall. PMID 11897506. 
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  • Ferguson KM. Active and inactive conformations of the epidermal growth factor receptor. Biochem. Soc. Trans.. 2005, 32 (Pt 5): 742–5. Error: Bad DOI specified模板:Namespace detect showall. PMID 15494003. 
  • Chao C, Hellmich MR. Bi-directional signaling between gastrointestinal peptide hormone receptors and epidermal growth factor receptor. Growth Factors. 2005, 22 (4): 261–8. Error: Bad DOI specified模板:Namespace detect showall. PMID 15621729. 
  • Carlsson J, Ren ZP, Wester K, et al.. Planning for intracavitary anti-EGFR radionuclide therapy of gliomas. Literature review and data on EGFR expression. J. Neurooncol.. 2006, 77 (1): 33–45. Error: Bad DOI specified模板:Namespace detect showall. PMID 16200342. 
  • Scartozzi M, Pierantoni C, Berardi R, et al.. Epidermal growth factor receptor: a promising therapeutic target for colorectal cancer. Anal. Quant. Cytol. Histol.. 2006, 28 (2): 61–8. PMID 16637508. 
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  • Cohenuram M, Saif MW. Epidermal growth factor receptor inhibition strategies in pancreatic cancer: past, present and the future. JOP. 2007, 8 (1): 4–15. PMID 17228128. 
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外部链接

模板:酶联受体 模板:生长因子受体

模板:Link GA

参考来源