查看“百利天恒”的源代码

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            <strong>[[百利天恒]]</strong>（<strong>[[Biokin Pharmaceutical]]</strong>）是一家总部位于[[中国]][[成都]]，并在[[美国]][[西雅图]]设有研发中心（<strong>[[SystImmune]]</strong>）的全球化[[创新药]]领军企业。公司专注于<strong>[[抗体偶联药物]]</strong>（<strong>[[ADC]]</strong>）、<strong>[[双特异性抗体]]</strong>及<strong>[[四特异性抗体]]</strong>（[[GNC]]平台）的开发。[[百利天恒]]凭借其旗舰产品<strong>[[BL-B01D1]]</strong>（全球首款进入临床的[[EGFR]]×[[HER3]]双靶点ADC）与全球制药巨头<strong>[[百时美施贵宝]]</strong>（<strong>[[BMS]]</strong>）达成了涉及[[84亿美元]]的战略授权合作，刷新了国产[[创新药]]出海的历史纪录。当前，公司已构建起涵盖[[非小细胞肺癌]]、[[乳腺癌]]及[[消化道肿瘤]]的深厚[[精准医疗]]管线。
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            <div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">[[百利天恒]] (Biokin)</div>
            <div style="font-size: 0.75em; opacity: 0.85; margin-top: 4px;">ADC与多抗领域全球领军者 · 点击展开</div>
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                <div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">核心资产：[[BL-B01D1]]</div>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; width: 40%;">股票代码</th>
                    <td style="padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">688506.SH</td>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">首席执行官</th>
                    <td style="padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">[[朱义]]</td>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">关键技术</th>
                    <td style="padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">[[ADC]]•[[GNC]]•[[BsAb]]</td>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">核心靶点</th>
                    <td style="padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">[[EGFR]] / [[HER3]] / [[PD-L1]]</td>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">[[Entrez]]ID</th>
                    <td style="padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">1956([[EGFR]])</td>
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                    <th style="text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569;">研发中心</th>
                    <td style="padding: 12px; color: #0f172a;">[[成都]] / [[西雅图]]</td>
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    <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">技术核心：从双抗ADC到四特异性抗体</h2>
    
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        [[百利天恒]]的核心竞争力在于其对复杂[[生物大分子]]结构的工程化能力，主要体现在以下三大平台：
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        <li style="margin-bottom: 12px;"><strong>[[双特异性ADC]]平台：</strong>代表作<strong>[[BL-B01D1]]</strong>通过同时靶向[[EGFR]]和[[HER3]]，不仅增强了对肿瘤细胞的识别特异性，还能通过阻断[[旁路信号]]协同克服[[耐药性]]，这种“双靶点+强效载药”的设计显著拓宽了[[治疗窗口]]。</li>
        <li style="margin-bottom: 12px;"><strong>[[GNC]]四抗平台：</strong>作为全球首创的[[四特异性抗体]]平台，该技术能同时结合肿瘤抗原、[[CD3]]、[[CD28]]及[[4-1BB]]。通过激活自身[[T细胞]]并引导其精准杀伤肿瘤，旨在解决[[实体瘤]]免疫治疗浸润不足的瓶颈。</li>
        <li style="margin-bottom: 12px;"><strong>[[全产业链整合]]：</strong>公司实现了从[[抗体发现]]、[[抗原]]制备到[[化学合成]]、[[偶联工艺]]的完全自主研发，确保了如<strong>[[SI-B001]]</strong>（[[EGFR]]×[[HER3]]双抗）等管线的高效推进。</li>
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                <th style="padding: 10px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">产品代码</th>
                <th style="padding: 10px; border: 1px solid #cbd5e1; color: #475569;">靶点/类别</th>
                <th style="padding: 10px; border: 1px solid #cbd5e1; color: #1e40af;">当前临床/商业地位</th>
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                <td style="padding: 8px; border: 1px solid #cbd5e1; font-weight: 600;">[[BL-B01D1]]</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">[[EGFR]]×[[HER3]] [[ADC]]</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">核心大单品，[[III期]]研究推进中；获[[BMS]]全球合作，针对[[肺癌]]展现突破性疗效。</td>
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                <td style="padding: 8px; border: 1px solid #cbd5e1; font-weight: 600;">[[SI-B001]] ([[EMB01]])</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">[[EGFR]]×[[HER3]] [[双抗]]</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">处于[[III期]]临床阶段，旨在解决[[EGFR-TKI]]耐药后的续贯治疗。</td>
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                <td style="padding: 8px; border: 1px solid #cbd5e1; font-weight: 600;">[[GNC-038]]</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">[[四特异性抗体]]</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">针对[[非霍奇金淋巴瘤]]，作为全球首款进入临床的四抗备受期待。</td>
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                <td style="padding: 8px; border: 1px solid #cbd5e1; font-weight: 600;">[[BL-M07D1]]</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">[[HER2]] [[ADC]]</td>
                <td style="padding: 8px; border: 1px solid #cbd5e1;">针对[[乳腺癌]]及[[胃癌]]，采用新型[[Topoisomerase I]]抑制剂载荷。</td>
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    <p style="margin: 15px 0; text-align: justify;">
        [[百利天恒]]在当前的发展路径中体现了从“[[精细化仿制]]”向“[[源头创新]]”的彻底转型：
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        <li style="margin-bottom: 12px;"><strong>[[全球同步研发]]：</strong>通过位于西雅图的[[SystImmune]]平台，第一时间对接全球前沿[[免疫学]]理论，实现产品管线的[[First-in-class]]定位。</li>
        <li style="margin-bottom: 12px;"><strong>[[License-out]]策略：</strong>通过与[[百时美施贵宝]]等[[大药企]]（[[MNC]]）合作，利用其全球商业化网络加速创新药在[[欧美]]市场的落地。</li>
        <li style="margin-bottom: 12px;"><strong>[[多适应症]]突围：</strong>针对[[非小细胞肺癌]]这一大病种，通过[[ADC]]、[[双抗]]、[[化疗]]等多维度联用，构建竞争壁垒。</li>
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    <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">关键相关概念</h2>
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            <li style="margin-bottom: 8px;"><strong>[[BL-B01D1]]：</strong>目前国产出海交易额最高的[[ADC]]药物。</li>
            <li style="margin-bottom: 8px;"><strong>[[HER3]]：</strong>肿瘤旁路激活的关键受体，是[[百利天恒]]差异化布局的重中之重。</li>
            <li style="margin-bottom: 8px;"><strong>[[GNC平台]]：</strong>代表了当前[[多抗]]技术的最高复杂度与创新深度。</li>
            <li style="margin-bottom: 8px;"><strong>[[百时美施贵宝]] (BMS)：</strong>[[百利天恒]]最重要的全球战略合作伙伴。</li>
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        <span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献与权威点评</span>
        
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            [1] <strong>Zhang L, et al. (2024).</strong> <em>BL-B01D1, a first-in-class EGFRxHER3 bispecific ADC, in patients with locally advanced or metastatic solid tumors.</em> <strong>[[The Lancet Oncology]]</strong>.[Academic Review]<br>
            <span style="color: #475569;">[权威点评]：该研究证实了双靶点ADC在克服EGFR单靶点治疗耐药方面的巨大潜力。</span>
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        <p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;">
            [2] <strong>Biokin Pharmaceutical. (2025).</strong> <em>Strategic Partnership Update with Bristol Myers Squibb on BL-B01D1 Global Development.</em> <strong>[[SSE Disclosures]]</strong>.<br>
            <span style="color: #475569;">[核心价值]：记录了百利天恒创新管线走向国际舞台的商业里程碑。</span>
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            [[百利天恒]] ([[Biokin]]) 企业诊疗生态 · 知识图谱
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">关联靶点</td>
                <td style="padding: 10px 15px; color: #334155;">[[EGFR]]•[[HER3]]•[[HER2]]•[[PD-1]]•[[CD3]]•[[4-1BB]]</td>
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">研发实体</td>
                <td style="padding: 10px 15px; color: #334155;">[[百利药业]]•[[SystImmune]]•[[百利天恒研发中心]]</td>
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">战略合作伙伴</td>
                <td style="padding: 10px 15px; color: #334155;">[[百时美施贵宝]](BMS)•[[NMPA]]•[[FDA]]</td>
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                <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">研究前沿</td>
                <td style="padding: 10px 15px; color: #334155;">[[多靶点ADC的抗耐药机制]]•[[四特异性抗体激活T细胞疗法]]•[[ADC联合PD-1一线肺癌探索]]</td>
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