查看“冷缺血时间”的源代码

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    <h2 style="border-left: 6px solid #1e40af; background: linear-gradient(to right, #eff6ff, #ffffff); color: #1e3a8a; padding: 12px 20px; font-size: 1.25em; margin-top: 40px; font-weight: bold; border-radius: 0 8px 8px 0;">典型谱系：临床四大“免疫荒漠”</h2>
    
    <p style="margin: 15px 0 25px 0; text-align: justify; color: #475569;">
        以下四类肿瘤是临床最典型的原发性耐药代表。新一代疗法正针对其独特的“荒漠化”机制（如物理屏障、信号缺陷）进行精准突围。
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        <table style="width: 100%; border-collapse: collapse; font-size: 0.95em; text-align: left; background-color: #ffffff;">
            
            <thead>
                <tr style="background-color: #1e3a8a; color: #ffffff;">
                    <th style="padding: 16px 20px; font-weight: 600; width: 22%; border-right: 1px solid #3b82f6;">肿瘤类型</th>
                    <th style="padding: 16px 20px; font-weight: 600; width: 43%; border-right: 1px solid #3b82f6;">荒漠化核心壁垒 (Barrier)</th>
                    <th style="padding: 16px 20px; font-weight: 600; width: 35%;">临床破局策略 (Breakthrough)</th>
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            <tbody>
                
                <tr style="border-bottom: 1px solid #e2e8f0;">
                    <td style="padding: 18px 20px; vertical-align: top; background-color: #f8fafc;">
                        <div style="font-size: 1.05em; font-weight: bold; color: #0f172a;">胰腺导管腺癌</div>
                        <div style="font-size: 0.85em; color: #64748b; margin-top: 4px;">PDAC</div>
                    </td>
                    <td style="padding: 18px 20px; vertical-align: top; border-right: 1px solid #f1f5f9;">
                        <span style="background-color: #fee2e2; color: #991b1b; padding: 2px 8px; border-radius: 4px; font-size: 0.85em; font-weight: bold;">物理屏障</span>
                        <p style="margin: 8px 0 0 0; line-height: 1.5; color: #334155;">
                            极度致密的纤维化基质（Desmoplasia）如同“城墙”，物理阻隔 T 细胞浸润；同时富含 MDSC 抑制细胞。
                        </p>
                    </td>
                    <td style="padding: 18px 20px; vertical-align: top;">
                        <span style="background-color: #dcfce7; color: #166534; padding: 2px 8px; border-radius: 4px; font-size: 0.85em; font-weight: bold;">基质耗竭</span>
                        <p style="margin: 8px 0 0 0; line-height: 1.5; color: #334155;">
                            联合 <strong>AG化疗</strong> (白蛋白紫杉醇+吉西他滨)；研发中的 <strong>CD40激动剂</strong>。
                        </p>
                    </td>
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                <tr style="border-bottom: 1px solid #e2e8f0;">
                    <td style="padding: 18px 20px; vertical-align: top; background-color: #ffffff;">
                        <div style="font-size: 1.05em; font-weight: bold; color: #0f172a;">前列腺癌</div>
                        <div style="font-size: 0.85em; color: #64748b; margin-top: 4px;">Prostate Ca.</div>
                    </td>
                    <td style="padding: 18px 20px; vertical-align: top; border-right: 1px solid #f1f5f9;">
                        <span style="background-color: #e0f2fe; color: #075985; padding: 2px 8px; border-radius: 4px; font-size: 0.85em; font-weight: bold;">信号缺失</span>
                        <p style="margin: 8px 0 0 0; line-height: 1.5; color: #334155;">
                            TMB 极低（缺乏靶标）+ <strong>PTEN缺失</strong>。PTEN 丢失导致 PI3K 通路激活，直接抑制抗原呈递机制。
                        </p>
                    </td>
                    <td style="padding: 18px 20px; vertical-align: top;">
                        <span style="background-color: #dcfce7; color: #166534; padding: 2px 8px; border-radius: 4px; font-size: 0.85em; font-weight: bold;">合成致死</span>
                        <p style="margin: 8px 0 0 0; line-height: 1.5; color: #334155;">
                            联合 <strong>[[PARP抑制剂]]</strong> (如奥拉帕利)；或采用 <strong>PSMA</strong> 靶向放射配体疗法。
                        </p>
                    </td>
                </tr>

                <tr style="border-bottom: 1px solid #e2e8f0;">
                    <td style="padding: 18px 20px; vertical-align: top; background-color: #f8fafc;">
                        <div style="font-size: 1.05em; font-weight: bold; color: #0f172a;">MSS 结直肠癌</div>
                        <div style="font-size: 0.85em; color: #64748b; margin-top: 4px;">MSS CRC</div>
                    </td>
                    <td style="padding: 18px 20px; vertical-align: top; border-right: 1px solid #f1f5f9;">
                        <span style="background-color: #ffedd5; color: #9a3412; padding: 2px 8px; border-radius: 4px; font-size: 0.85em; font-weight: bold;">WNT 激活</span>
                        <p style="margin: 8px 0 0 0; line-height: 1.5; color: #334155;">
                            APC 突变激活 WNT/β-catenin 通路，直接抑制 DC 细胞的招募，导致 T 细胞无法在淋巴结启动 (Priming Failure)。
                        </p>
                    </td>
                    <td style="padding: 18px 20px; vertical-align: top;">
                        <span style="background-color: #dcfce7; color: #166534; padding: 2px 8px; border-radius: 4px; font-size: 0.85em; font-weight: bold;">微环境调节</span>
                        <p style="margin: 8px 0 0 0; line-height: 1.5; color: #334155;">
                            联合 <strong>[[抗血管生成]] TKI</strong> (如瑞戈非尼、呋喹替尼) 调节微环境。
                        </p>
                    </td>
                </tr>

                <tr>
                    <td style="padding: 18px 20px; vertical-align: top; background-color: #ffffff;">
                        <div style="font-size: 1.05em; font-weight: bold; color: #0f172a;">小细胞肺癌</div>
                        <div style="font-size: 0.85em; color: #64748b; margin-top: 4px;">SCLC</div>
                    </td>
                    <td style="padding: 18px 20px; vertical-align: top; border-right: 1px solid #f1f5f9;">
                        <span style="background-color: #f3e8ff; color: #6b21a8; padding: 2px 8px; border-radius: 4px; font-size: 0.85em; font-weight: bold;">呈递缺陷</span>
                        <p style="margin: 8px 0 0 0; line-height: 1.5; color: #334155;">
                            <strong>高TMB悖论</strong>：尽管因吸烟导致高突变，但 MHC-I 类分子普遍下调，“空有抗原，无法呈递”。
                        </p>
                    </td>
                    <td style="padding: 18px 20px; vertical-align: top;">
                        <span style="background-color: #dcfce7; color: #166534; padding: 2px 8px; border-radius: 4px; font-size: 0.85em; font-weight: bold;">不依赖 MHC</span>
                        <p style="margin: 8px 0 0 0; line-height: 1.5; color: #334155;">
                            使用 <strong>[[DLL3双抗]]</strong> (Tarlatamab)，物理拉动 T 细胞杀伤，无需 MHC 参与。
                        </p>
                    </td>
                </tr>

            </tbody>
        </table>
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