查看“代谢重塑”的源代码

<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 900px; margin: auto;"><div style="margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;"><p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"><strong>MSC</strong>（Mesenchymal Stem Cells，间充质干细胞）系源于中胚层的一类具自我更新能力与多向分化潜能的非造血多能干细胞。其核心生物学特征在于卓越的<strong>[[旁分泌效应]]</strong>与<strong>[[免疫调节]]</strong>能力。作为[[细胞治疗]]的核心分支，MSC 在逆转[[GvHD]]（移植物抗宿主病）、改善[[中枢神经系统损伤]]及重塑[[肿瘤微环境]]等领域展现出巨大的临床价值。</p></div><div class="medical-infobox mw-collapsible" style="width: 100%; max-width: 340px; margin: 0 auto 35px auto; border: 1.2px solid #cbd5e1; border-radius: 10px; background-color: #ffffff; box-shadow: 0 8px 20px rgba(0,0,0,0.06); overflow: hidden;"><div style="padding: 16px; color: #ffffff; background: linear-gradient(135deg, #1e3a8a 0%, #3b82f6 100%); text-align: center; cursor: pointer;">
    <div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1px;">MSC · 生物学概要</div>
    <div style="font-size: 0.75em; opacity: 0.85; margin-top: 4px;">Mesenchymal Stem Cells Profile</div>
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            [[文件:MSC_Differentiation_Landscape.png|180px|MSC 分化潜能示意]]
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        <div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 500;">图：MSC 表面标志物与多向分化</div>
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            <th style="text-align: left; padding: 10px 15px; border-bottom: 1px solid #f1f5f9; color: #475569; background-color: #f8fafc; width: 40%;">阳性标志物</th>
            <td style="padding: 10px 15px; border-bottom: 1px solid #f1f5f9; color: #0f172a;">$CD73^+, CD90^+, CD105^+$</td>
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            <th style="text-align: left; padding: 10px 15px; border-bottom: 1px solid #f1f5f9; color: #475569; background-color: #f8fafc;">阴性标志物</th>
            <td style="padding: 10px 15px; border-bottom: 1px solid #f1f5f9; color: #0f172a;">$CD34^-, CD45^-, HLA\text{-}DR^-$</td>
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            <th style="text-align: left; padding: 10px 15px; color: #475569; background-color: #f8fafc;">核心机制</th>
            <td style="padding: 10px 15px; color: #2563eb; font-weight: 600;">[[免疫抑制]] / [[组织修复]]</td>
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</div><h2 style="background: #f1f5f9; color: #1e3a8a; padding: 10px 15px; border-radius: 0 4px 4px 0; font-size: 1.2em; margin-top: 40px; border-left: 5px solid #1e3a8a; font-weight: bold;">作用机制：精准归巢与免疫重塑</h2><p style="margin: 15px 0; text-align: justify;">MSC 的临床潜力主要源于其对损伤信号的敏感响应及对局部微环境的深度干预：</p><ul style="padding-left: 20px; color: #334155; list-style-type: square;"><li style="margin-bottom: 12px;"><strong>定向[[归巢机制]]（Homing）：</strong> 受趋化因子（如 CXCL12/SDF-1 轴）驱动，MSC 能穿透内皮屏障，精准募集至炎症或缺血病灶。</li><li style="margin-bottom: 12px;"><strong>[[免疫调节]]轴点：</strong> 分泌 $PGE_2$、$IDO$ 等活性因子，抑制过激的 [[效应T细胞]] 反应，诱导 [[Treg]] 细胞扩增。</li><li style="margin-bottom: 12px;"><strong>无细胞干预潜能：</strong> 现代研究聚焦于 <strong>MSC 外泌体</strong>，认为其携带的微 RNA 与蛋白质可模拟母体细胞的修复效应。</li></ul><h2 style="background: #f1f5f9; color: #1e3a8a; padding: 10px 15px; border-radius: 0 4px 4px 0; font-size: 1.2em; margin-top: 40px; border-left: 5px solid #1e3a8a; font-weight: bold;">MSC 与效应 T 细胞之药理学特性对照</h2><div style="overflow-x: auto; margin: 25px 0;"><table style="width: 92%; margin: 0 auto; border-collapse: collapse; border: 1px solid #e2e8f0; font-size: 0.9em; text-align: left;"><tr style="background-color: #f8fafc; border-bottom: 2px solid #1e3a8a;"><th style="padding: 12px; border: 1px solid #e2e8f0; color: #1e3a8a;">特性维度</th><th style="padding: 12px; border: 1px solid #e2e8f0; color: #475569;">效应 T 细胞 (如 [[CAR-T]])</th><th style="padding: 12px; border: 1px solid #e2e8f0; color: #16a34a;">间充质干细胞 (MSC)</th></tr><tr><td style="padding: 10px; border: 1px solid #e2e8f0; font-weight: bold;">主导功能</td><td style="padding: 10px; border: 1px solid #e2e8f0;">靶向抗原杀伤</td><td style="padding: 10px; border: 1px solid #e2e8f0;">炎症平抑与组织再生</td></tr><tr><td style="padding: 10px; border: 1px solid #e2e8f0; font-weight: bold;">HLA 表达</td><td style="padding: 10px; border: 1px solid #e2e8f0;">高度依赖 (需严格配型)</td><td style="padding: 10px; border: 1px solid #e2e8f0;">极低 (具[[免疫豁免]]特性)</td></tr><tr><td style="padding: 10px; border: 1px solid #e2e8f0; font-weight: bold;">典型应用</td><td style="padding: 10px; border: 1px solid #e2e8f0;">血液肿瘤清除</td><td style="padding: 10px; border: 1px solid #e2e8f0;">[[GvHD防控]]、自身免疫病</td></tr></table></div><div style="font-size: 0.88em; line-height: 1.6; color: #334155; margin-top: 50px; border-top: 2px solid #1e3a8a; padding-top: 20px; background-color: #f8fafc; padding: 25px; border-radius: 8px;"><strong style="color: #1e3a8a; font-size: 1.1em; display: block; margin-bottom: 15px;">权威参考文献（严格审校）</strong><p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 12px;">
    [1] <strong>Friedenstein A J, et al. (1970).</strong> <em>The development of fibroblast colonies in monolayer cultures...</em> <strong>Cell and Tissue Kinetics</strong>. <br>
    <span style="color: #64748b; font-size: 0.95em;">[学术点评]：该研究奠定了 MSC 在骨髓基质中作为成纤维细胞集落形成单位（CFU-F）的生物学定义。</span>
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    [2] <strong>Pittenger M F, et al. (1999).</strong> <em>Multilineage potential of adult human mesenchymal stem cells.</em> <strong>Science</strong>. <br>
    <span style="color: #64748b; font-size: 0.95em;">[学术点评]：里程碑式论文，正式在克隆水平证实了人源 MSC 的成骨、成软骨及成脂多向分化潜能。</span>
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    [3] <strong>Le Blanc K, et al. (2008).</strong> <em>Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease.</em> <strong>The Lancet</strong>. <br>
    <span style="color: #64748b; font-size: 0.95em;">[学术点评]：该临床研究确立了 MSC 作为激素耐药型急性 GvHD 重要救治手段的科学地位。</span>
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</div><div style="margin: 40px 0; border: 1px solid #cbd5e1; border-radius: 6px; overflow: hidden;"><div style="background-color: #f1f5f9; color: #1e3a8a; text-align: center; font-weight: bold; padding: 8px; font-size: 0.9em; letter-spacing: 1px;">MSC 知识图谱关联</div><div style="padding: 15px; background: #ffffff; line-height: 2; text-align: center; font-size: 0.9em;">[[归巢机制]] • [[GvHD防控]] • [[MSC外泌体]] • [[中胚层发育]] • [[再生医学]] • [[单细胞测序质控]]</div></div></div>