查看“HER2/neu”的源代码

{{PBB|geneid=2064}}

'''人类[[表皮生长因子受体]]2'''（{{lang-en|'''human epidermal growth factor receptor 2'''}}，缩写为'''HER2'''，亦称为'''Neu'''、'''[[ErbB]]-2'''、'''CD340'''（[[分化]]群340）或'''p185'''）是一种由''ERBB2''[[基因]]编码的[[蛋白质]]。HER2是表皮生长因子受体（EGFR/ErbB）家族中的成员之一。

== 功能 ==

HER2是结合在[[细胞膜]]表面的[[受体酪氨酸激酶]]，参与导致[[细胞]]生长和分化的信号[[传导]]途径，由[[原癌基因]]'''HER2/neu'''编码。一般认为HER2是一个孤[[受体]]，[[表皮生长因子]]家族的[[配体]]都不能激活它。但配体结合ErbB受体时可形成[[二聚体]]，且HER2可与ErbB家族的其他成员结合成异二聚体。<ref name="Olayioye_2001">{{cite journal |author=Olayioye MA|title=Update on HER-2 as a target for cancer therapy: intracellular signaling pathways of ErbB2/HER-2 and family members|journal= Breast Cancer Res |volume= 3 |issue= 6 |pages= 385–389 |year= 2001|doi= 10.1186/bcr327 |pmid= 11737890}}</ref>HER2基因是原癌基因，位于人类第17号[[染色]]体长臂（17q21-q22）。<ref name="Coussens_1985">{{cite journal |author=Coussens L|title=Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene|journal= Science |volume=230 |pages= 1132–1139 |year= 1985 |doi=10.1126/science.2999974}}</ref>

== 与[[癌症]]的关系 ==

HER-2基因是影响[[乳癌]]预后的一个重要因素，大约有25%-30%左右的乳癌患者，受到体内[[癌细胞]]HER-2基因过量表现的影响，他们的癌细胞不仅繁殖能力强，对部份[[化学治疗]]药物也容易有[[抗药性]]，造成病患即使接受[[手术治疗]]，癌细胞仍然有较高复发及转移的机率，无法长期存活。

乳癌病患可分为Her-2/neu阳性或Her-2/neu阴性两种截然不同的预后之乳癌。乳癌患者的[[肿瘤]]，若HER-2蛋白质出现过量表现，这类的肿瘤生长速度较快且生物行为较为恶性，使得手术后复发率高于其他类型的乳癌。<ref>{{cite web|url=http://cisc.twbbs.org/lifetype/index.php?op=ViewArticle&articleId=1813&blogId=1|title=HER-2阳性早期乳癌治疗的近况|publisher= 台湾癌症防治网 |author= |date=2009年10月16日 |accessdate=2009-10-06}}</ref>

== 针对HER2的葯物 ==

[[罗氏药厂]]开发的[[贺癌平]]（Herceptin)即是以'''HER2'''为标靶的葯物，对晚期转移性的[[乳腺癌]]颇具效用。

== 相互作用 ==

== 参考文献 ==

{{Reflist}}

==深入阅读==

{{refbegin|colwidth=35em}}
*{{cite journal  | author=Ross JS, Fletcher JA, Linette GP, ''et al.'' |title=The Her-2/neu gene and protein in breast cancer 2003: biomarker and target of therapy |journal=Oncologist |volume=8 |issue= 4 |pages= 307–25 |year= 2003 |pmid= 12897328 |doi=10.1634/theoncologist.8-4-307  }}
*{{cite journal  | author=Zhou BP, Hung MC |title=Dysregulation of cellular signaling by HER2/neu in breast cancer |journal=Semin. Oncol. |volume=30 |issue= 5 Suppl 16 |pages= 38–48 |year= 2003 |pmid= 14613025 |doi=10.1053/j.seminoncol.2003.08.006  }}
*{{cite journal  | author=Ménard S, Casalini P, Campiglio M, ''et al.'' |title=Role of HER2/neu in tumor progression and therapy |journal=Cell. Mol. Life Sci. |volume=61 |issue= 23 |pages= 2965–78 |year= 2005 |pmid= 15583858 |doi= 10.1007/s00018-004-4277-7 }}
*{{cite journal  | author=Becker JC, Muller-Tidow C, Serve H, ''et al.'' |title=Role of receptor tyrosine kinases in gastric cancer: new targets for a selective therapy |journal=World J. Gastroenterol. |volume=12 |issue= 21 |pages= 3297–305 |year= 2006 |pmid= 16733844 |doi=  }}
*{{cite journal  | author=Laudadio J, Quigley DI, Tubbs R, Wolff DJ |title=HER2 testing: a review of detection methodologies and their clinical performance |journal=Expert Rev. Mol. Diagn. |volume=7 |issue= 1 |pages= 53–64 |year= 2007 |pmid= 17187484 |doi= 10.1586/14737159.7.1.53 }}
*{{cite journal  | author=Bianchi F, Tagliabue E, Ménard S, Campiglio M |title=Fhit expression protects against HER2-driven breast tumor development: unraveling the molecular interconnections |journal=Cell Cycle |volume=6 |issue= 6 |pages= 643–6 |year= 2007 |pmid= 17374991 |doi=  10.4161/cc.6.6.4033}}
*{{cite journal  | author=Del Bimbo A.,  Meoni M.,   Pala P.   |title=Accurate evaluation of HER-2 amplification in FISH images |journal=Imaging Systems and Techniques (IST), 2010 IEEE International Conference on |pages= 407–10 |year= 2010 |doi=  10.1109/IST.2010.5548461  | isbn=978-1-4244-6492-0 }}
{{refend}}

== 外部链接 ==
* [http://medisapiens.com/ERBB2 ERBB2 expression across human cancerous and healthy tissues]
* [http://www.aacr.org/home/public--media/for-the-media/fact-sheets/cancer-concepts/her2.aspx AACR Cancer Concepts Factsheet on HER2]
* [http://logikbase.com/website/techprofile.cfm?licid=1027 Her2/neu Vaccine Protects Against Tumor Growth ]
* [http://logikbase.com/website/techprofile.cfm?licid=618 Chimeric molecules and Methods of Use]
* [http://www.her2.co.za/care/ Breast Friends for Life Network - A South African Breast Cancer Support Forum for HER2 Positive Women]
* {{MeshName|Receptor,+erbB-2}}

{{-}}
{{PDB Gallery|geneid=2064}}
{{酪氨酸激酶类}}
<!-- {{分化群}} -->
{{癌基因}}
<!-- {{肿瘤标志物}} -->

{{DEFAULTSORT:Her2 Neu}} [[Category:分化群]] [[Category:酪氨酸激酶受体]] [[Category:基因]]
==参考来源==
*[http://zh.wikipedia.org/wiki/HER2%2Fneu 维基百科-HER2/neu]