肌球蛋白轻链激酶

来自医学百科

模板:Protein 模板:Protein 模板:Protein 模板:Protein 肌球蛋白轻链激酶（英文名：Myosin light-chain kinase，MYLK 或 MLCK）是一类丝氨酸/苏氨酸特异性蛋白激酶，通过磷酸化来调节II型肌球蛋白的轻链[1]。

亚型

现存四种MLCK亚型[2]主要分布于不同肌细胞：

功能

另见

参考文献

  1. ↑ Gao Y, Ye LH, Kishi H, Okagaki T, Samizo K, Nakamura A, Kohama K. Myosin light chain kinase as a multifunctional regulatory protein of smooth muscle contraction. IUBMB Life. June 2001, 51 (6): 337–44. Error: Bad DOI specified模板:Namespace detect showall. PMID 11758800. 
  2. ↑ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. December 2002, 298 (5600): 1912–34. Error: Bad DOI specified模板:Namespace detect showall. PMID 12471243. 

延伸阅读

  • Strausberg RL, Feingold EA, Grouse LH, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/ Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.]. Proc. Natl. Acad. Sci. U.S.A.. 2003, 99 (26): 16899–903. Error: Bad DOI specified模板:Namespace detect showall. PMID 12477932. PMC 139241. 
  • Gerhard DS, Wagner L, Feingold EA, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/ The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).]. Genome Res.. 2004, 14 (10B): 2121–7. Error: Bad DOI specified模板:Namespace detect showall. PMID 15489334. PMC 528928. 
  • Clayburgh DR, Rosen S, Witkowski ED, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1237105/ A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.]. J. Biol. Chem.. 2005, 279 (53): 55506–13. Error: Bad DOI specified模板:Namespace detect showall. PMID 15507455. PMC 1237105. 
  • Wang F, Graham WV, Wang Y, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1237049/ Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.]. Am. J. Pathol.. 2005, 166 (2): 409–19. Error: Bad DOI specified模板:Namespace detect showall. PMID 15681825. PMC 1237049. 
  • Russo JM, Florian P, Shen L, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1237051/ Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.]. Gastroenterology. 2005, 128 (4): 987–1001. Error: Bad DOI specified模板:Namespace detect showall. PMID 15825080. PMC 1237051. 
  • Shimizu S, Yoshida T, Wakamori M, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1464317/ Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.]. J. Physiol. (Lond.). 2006, 570 (Pt 2): 219–35. Error: Bad DOI specified模板:Namespace detect showall. PMID 16284075. PMC 1464317. 
  • Kim MT, Kim BJ, Lee JH, et al.. Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells.. Am. J. Physiol., Cell Physiol.. 2006, 290 (4): C1031–40. Error: Bad DOI specified模板:Namespace detect showall. PMID 16306123. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1356129/ Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.]. Genome Res.. 2006, 16 (1): 55–65. Error: Bad DOI specified模板:Namespace detect showall. PMID 16344560. PMC 1356129. 
  • Connell LE, Helfman DM. Myosin light chain kinase plays a role in the regulation of epithelial cell survival.. J. Cell. Sci.. 2007, 119 (Pt 11): 2269–81. Error: Bad DOI specified模板:Namespace detect showall. PMID 16723733. 
  • Seguchi O, Takashima S, Yamazaki S, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1978424/ A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.]. J. Clin. Invest.. 2007, 117 (10): 2812–24. Error: Bad DOI specified模板:Namespace detect showall. PMID 17885681. PMC 1978424. 

外部链接

模板:NLM content

参考来源

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